MSc: Neutrophil Extracellular Traps in Rheumatoid Arthritis
Your Role
Job TitleMSc: Neutrophil Extracellular Traps in Rheumatoid Arthritis
Duties and ResponsibilitiesThe successful candidate will work within the Manitoba Centre for Proteomics and Systems Biology (7th floor John Buhler Research Centre). They will receive training in biosafety and research ethics, learn and develop biomedical laboratory techniques, receive mentorship from Dr. O'Neil and senior laboratory members, learn data analysis methods and present results at weekly lab meetings.
See https://umanitoba.ca/explore/programs-of-study/immunology-msc for further details
Skills and Benefits to be Gained from this PositionLaboratory techniques including cell culture, flow cytometry, mass spectrometry, ELISA, real time PCR, neutrophil isolation, NET generation, immunofluorescence. Analytical approaches in R. Communal/shared laboratory space, opportunity for collaboration and exposure to other trainees and faculty.
Involvement of Animals, Humans and/or HazardsHumansYes
How to Apply
DeadlineMay 18, 2022(Open until filled)
University LevelGraduate
Application MethodEmail
Required Application Materials
- Resume
- Cover Letter
- Transcript
- A statement indicating the school, program and year that you are currently enrolled in.
References1(liam.oneil@umaniitoba.ca)
The Project
Project TitleDysregulated neutrophil extracellular trap formation in Rheumatoid Arthritis
Project DescriptionNeutrophils, the most abundant circulating human leukocyte, are critical for immune responses to invading pathogens. In certain circumstances, neutrophils have been shown to form extracellular traps, called NETs, that consist of self-DNA and cytotoxic proteins. During this process, proteins are modified with citrulline, a post-translational modification. In RA, NET formation is dysregulated and citrullinated proteins extruded into the extracellular space may act as RA autoantigens. Thus, NETs have the potential to mediate important aspects of RA pathogenesis. We aim to elucidate the role of enhanced NET formation in both established RA, and in individuals with RA autoantibodies towards citrulline (called ACPA), who are at-risk to develop RA.
Researcher/SupervisorDr. Liam O'Neil
FacultyRady Faculty of Health Sciences
Department/SchoolImmunology
Phone2047997856
Job Terms
Number of Jobs1
Job DatesASAP to [tbd]
Hours Per Week40
Salary19000
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