Biomolecular Grammar for Protein Aggregation Modulation and Intervention (BIOGAMI)

The BIOGAMI program aims to stop diseases like Alzheimer’s and other brain disorders by finding and fixing problems with proteins very early—before they clump together and damage cells. The program has two technical focus areas: (1) build next-generation artificial intelligence and experimental models for intrinsically disordered proteins (IDPs) and aggregation; and (2) leverage novel tools to develop novel therapeutic modalities that interfere with or prevent IDP misfolding and aggregation while preserving critical functions, and create novel detection capabilities that respond to early-stage IDP aggregation.