Project TitleIdentifying novel transcriptional regulators of beta cell senescence in Type 1 Diabetes
Project DescriptionA summer undergraduate research position is available in the laboratory of Dr. Peter Thompson, in the Children's Hospital Research Institute of Manitoba (CHRIM) at the Bannatyne campus. The Thompson lab investigates the molecular mechanisms of Type 1 Diabetes (T1D), a metabolic disease characterized by insulin deficiency due to autoimmune destruction of pancreatic beta cells. Learn more at the lab website: https://www.thompsonlab.ca
Previous work in the lab has demonstrated that some beta cells acquire a growth arrested, inflammatory state called senescence which drives the onset of T1D. How this state is regulated remains unclear. In this project, the student will address this research question using a mouse beta cell line model to identify new transcriptional regulators of senescence in beta cells. They will learn basic cell culture methods, biochemistry (protein immunoprecipitation & western blotting) and genetic tools to explore gene function and expression (RNA interference, quantitative PCR). This position is ideally suited for 2nd or 3rd year student with a background in molecular or cell biology, genetics or biochemistry.
The student will apply with Dr. Thompson for an Undergraduate Research Award (URA) for this position.
Researcher/SupervisorDr. Peter Thompson
FacultyRady Faculty of Health Sciences
Department/SchoolPhysiology & Pathophysiology
Number of Jobs1
Job DatesMay 03, 2021 to August 27, 2021
Other InformationPosition contingent on summer undergraduate research award (URA) funding.